This webinar takes place on Tuesday July 9th between 16.00 and 16.30 CEST
/ 15.00-15.30 BST / 10.00-10.30 AM EDT / 7.00-7.30 AM PDT.
Follow the link to register for the webinar. Please note that the presentation will be given during the live event only and on demand viewing at a later date will not be possible. Contact us for any questions.
THIS WEBINAR IS ARRANGED BY CELLECTRICON AB. FOR MORE INFORMATION ON THE HANDLING OF YOUR PERSONAL INFORMATION, SEE OUR PRIVACY POLICY.
Abstract:
Chronic neuroinflammation is increasingly recognized as being a key player in the overall biology underlying neurodegenerative disease, and there is ample clinical data showing significant correlations between activated microglia and astrocytes, and neurodegenerative disease progression. Despite the longstanding recognition of their central role in chronic and degenerative diseases of the CNS, there is still a critical need for assay platforms that recapitulate the systems biology of microglia in a way that meaningfully facilitates neuroinflammatory drug discovery.
In this webinar, we will present a rodent-human chimeric assay platform that recapitulates many functional and phenotypic aspects of chronic neuroinflammation. The system permits quantification of functional and endpoint readouts relevant to neuronal and microglial function in the presence and absence of neuroinflammatory stimuli. The platform has been validated by targeting various aspects of neuroinflammatory biology and can be utilized for target validation as well as small molecule characterization.