In this webinar, we will discuss design and development of translational in vitro models with better validity for chronic pain drug discovery. We will discuss how to select between animal and human models for your discovery research and how to bridge between rodent-based and human neuronal assays as well as opportunities and limitations of human models from iPS cells and native human nerve tissue. We will also provide our view on how to address lack of efficacy as early as possible in the drug discovery path by sharing case studies from our lab and from the literature.
Finally, we will share our vision on how to develop “disease in a dish” microfluidic co-culture models to study the interaction between neuronal cells and target organs such as bone and skin in chronic pain. Applying optical electrophysiology in combination with a novel microfluidics platform, we aim to create unique high capacity in vitro assays as means to aid in the understanding of mechanisms of peripheral pain.
Wednesday, November 13 @ 5 pm CET / 11 am EST / 8 am PST