Innovative in vitro assays of enhanced translational value
Our assays fill the gap between less complex model systems, such as high throughput screening in over-expressing cell lines and in vivo animal models, and are enabling our Clients to better prioritize which molecules to advance into the clinic.
All aspect of the company’s collective experience, from engineering and product development to drug discovery, are integrated when devising and creating, new, innovative assays for our Clients. This can be exemplified by our work with integrating functional measurement of excitability with morphological readouts applying high content imaging to enable analysis of drug action on discrete subpopulations of neurons in sensory ganglia. This resulted in improved assay sensitivity that is instrumental in identifying compounds having subtle, modulatory effects and increases the odds of identifying treatments that restore abnormal excitability in chronic pain conditions.
Our discovery platform enables high capacity testing of changes in excitability and synaptic communication in native and iPSC-derived sensory neurons. The capacity can be applied not only for screening of large number of compounds but also to efficiently identify optimal assay parameters and thereby maximizing translatability.